Since email applications can distort the HTML message in the different ways, you need to keep your email design nice and simple. Avoid complicated layouts, too many tables, and tables with too many rows and columns. Many email applications don’t interpret the tables with colspans (table cells that "span" across multiple columns) in them. You should better insert more "simple" tables, than one big "complex" table. For example, you can use separate tables for the header, body, and footer of your emails. So, you have to keep your layouts very, very simple, if you want your HTML message to work across all the major email applications. Plus, a complex HTML newsletter will take a longer time to open, and you recipients won’t appreciate it.